Newport Fire Department and mutual aid responded to a second alarm fire at 36 Bacheller Street just before noon on Saturday.
The fire started in a second-floor bathroom, according to reports. All occupants are also reportedly out of the building.
Bacheller Street runs from Byrnes Street to Spring Street.
As of 1:10 pm, crews were still on scene and Spring Street at Spring and Dixon Street was closed.
This story is developing.